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Frederic J Seidler Selected Research

Terbutaline (Brethaire)

1/2018Developmental neurotoxicity resulting from pharmacotherapy of preterm labor, modeled in vitro: Terbutaline and dexamethasone, separately and together.
3/2013Terbutaline impairs the development of peripheral noradrenergic projections: potential implications for autism spectrum disorders and pharmacotherapy of preterm labor.
7/2007Developmental exposure to terbutaline and chlorpyrifos, separately or sequentially, elicits presynaptic serotonergic hyperactivity in juvenile and adolescent rats.
12/2005Imbalances emerge in cardiac autonomic cell signaling after neonatal exposure to terbutaline or chlorpyrifos, alone or in combination.
6/2005Critical periods for the role of oxidative stress in the developmental neurotoxicity of chlorpyrifos and terbutaline, alone or in combination.
3/2005Developmental exposure to terbutaline alters cell signaling in mature rat brain regions and augments the effects of subsequent neonatal exposure to the organophosphorus insecticide chlorpyrifos.
3/2005Developmental exposure to terbutaline and chlorpyrifos: pharmacotherapy of preterm labor and an environmental neurotoxicant converge on serotonergic systems in neonatal rat brain regions.
3/2004Does pharmacotherapy for preterm labor sensitize the developing brain to environmental neurotoxicants? Cellular and synaptic effects of sequential exposure to terbutaline and chlorpyrifos in neonatal rats.
2/2004Terbutaline is a developmental neurotoxicant: effects on neuroproteins and morphology in cerebellum, hippocampus, and somatosensory cortex.
1/2004Beta-adrenoceptor modulation of transiently overexpressed alpha 2-adrenoceptors in brain and peripheral tissues: cellular mechanisms underlying the developmental toxicity of terbutaline.
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Frederic J Seidler Research Topics

Disease

23Premature Obstetric Labor (Premature Labor)
01/2018 - 07/2003
7Neurodevelopmental Disorders
01/2018 - 10/2005
4Tobacco Use Disorder (Nicotine Dependence)
07/2008 - 10/2003
3Prediabetic State (Prediabetes)
05/2011 - 11/2008
3Cognitive Dysfunction
04/2010 - 01/2002
3Gliosis
03/2004 - 08/2003
2Weight Gain
05/2013 - 11/2008
2Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome)
11/2011 - 09/2005
2Obesity
04/2010 - 11/2008
2Body Weight (Weight, Body)
01/2010 - 09/2005
2Weight Loss (Weight Reduction)
11/2008 - 12/2003
1Heart Diseases (Heart Disease)
04/2016
1Hypertension (High Blood Pressure)
04/2016
1Autism Spectrum Disorder
03/2013
1Autistic Disorder (Autism)
03/2013
1Parkinson Disease (Parkinson's Disease)
11/2011
1Hypoxia (Hypoxemia)
05/2011
1Sudden Infant Death (SID)
05/2011
1Alzheimer Disease (Alzheimer's Disease)
11/2008
1Mental Disorders (Mental Disorder)
07/2007
1Substance Withdrawal Syndrome (Withdrawal Symptoms)
11/2006
1Atherosclerosis
10/2005
1Hyperinsulinism (Hyperinsulinemia)
10/2005
1Hyperlipidemias (Hyperlipidemia)
10/2005
1Type 2 Diabetes Mellitus (MODY)
10/2005
1Glioma (Gliomas)
05/2005
1Teratogenesis
02/2004
1Necrosis
12/2003
1Fetal Weight
11/2002
1Learning Disabilities (Learning Disability)
01/2002

Drug/Important Bio-Agent (IBA)

12Chlorpyrifos (Lorsban)IBA
12/2015 - 02/2004
12OrganophosphatesIBA
01/2014 - 02/2004
11Terbutaline (Brethaire)FDA LinkGeneric
01/2018 - 12/2003
11GlucocorticoidsIBA
01/2018 - 09/2005
10NicotineFDA Link
04/2016 - 10/2003
9Dexamethasone (Maxidex)FDA LinkGeneric
01/2018 - 09/2005
5PesticidesIBA
07/2013 - 03/2005
4SmokeIBA
01/2017 - 01/2002
4Adrenergic Receptors (Adrenergic Receptor)IBA
05/2011 - 02/2004
4Serotonin (5 Hydroxytryptamine)IBA
05/2011 - 03/2005
4Parathion (Ethyl Parathion)IBA
04/2010 - 11/2008
4Tocolytic Agents (Tocolytics)IBA
07/2007 - 07/2003
3Neurotransmitter Agents (Neurotransmitter)IBA
04/2010 - 07/2008
3DNA (Deoxyribonucleic Acid)IBA
05/2005 - 08/2003
3Cholinergic Agents (Cholinergics)IBA
03/2005 - 11/2002
3InsecticidesIBA
03/2005 - 02/2004
2Cholinesterases (Cholinesterase)IBA
05/2013 - 12/2005
2LipidsIBA
11/2008 - 10/2005
2Glucose (Dextrose)FDA LinkGeneric
11/2008 - 10/2005
2Adenylyl Cyclases (Adenylyl Cyclase)IBA
07/2008 - 05/2005
2Glial Fibrillary Acidic ProteinIBA
02/2004 - 08/2003
1Norepinephrine (Noradrenaline)FDA LinkGeneric
04/2016
1Benzo(a)pyreneIBA
07/2013
1Serotonin ReceptorsIBA
05/2011
1Ascorbic Acid (Vitamin C)FDA LinkGeneric
05/2011
1Dopamine (Intropin)FDA LinkGeneric
04/2010
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
01/2010
1LeptinIBA
01/2010
1AdiponectinIBA
01/2010
1alpha Adrenergic ReceptorsIBA
11/2008
1Acetylcholine (Acetylcholine Chloride)FDA Link
11/2008
1Cholinesterase Inhibitors (Anticholinesterases)IBA
11/2008
1Contrast MediaIBA
11/2008
1Memantine (Namenda)FDA Link
11/2008
1NicergolineIBA
11/2008
1PhysostigmineIBA
11/2008
1amyloid beta-protein (1-42)IBA
11/2008
1Tacrine (Cognex)FDA Link
11/2008
1N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA
11/2008
1Biological ProductsIBA
07/2008
1Insulin (Novolin)FDA Link
10/2005
1Reactive Oxygen Species (Oxygen Radicals)IBA
05/2005
1Transcription Factors (Transcription Factor)IBA
05/2005
1Proteins (Proteins, Gene)FDA Link
03/2004
1Biomarkers (Surrogate Marker)IBA
03/2004
1Neurofilament ProteinsIBA
02/2004
1Neurotransmitter Receptors (Neurotransmitter Receptor)IBA
01/2004

Therapy/Procedure

8Drug Therapy (Chemotherapy)
01/2018 - 03/2004
5Therapeutics
09/2012 - 02/2004
1Subcutaneous Injections
12/2003
1Tocolysis
12/2003